Is n,n'-methylenebisacrylamide safe during pregnancy?

Pregnancy-Safe Alternatives to n,n'-methylenebisacrylamide | VeriMom

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See also

• Is n,n'-methylenebisacrylamide safe for babies?
• Should I avoid n,n'-methylenebisacrylamide during pregnancy?
• What are pregnancy-safe alternatives to n,n'-methylenebisacrylamide?

Frequently asked questions

Is n,n'-methylenebisacrylamide safe during pregnancy?

There are peer‑reviewed developmental toxicity studies in mice reporting decreased fetal body weight and increased fetal variations with N,N'-methylenebisacrylamide (110-26-9), indicating suspected developmental hazard (NOAEL for developmental toxicity reported at 3 mg/kg/day; adverse effects at higher doses). No harmonised CLP (Annex VI) reproductive classification was identified. For typical topical cosmetic use, dermal exposure/absorption from finished products is expected to be negligible. (Toxicological Sciences 1998; ECHA substance information; product SDSs/MSDSs reporting reproductive hazard category in supplier documents).

Is n,n'-methylenebisacrylamide safe while breastfeeding?

Same basis as pregnancy: animal developmental/reproductive studies show suspected developmental toxicity. There are no data showing transfer into human milk; for normal topical cosmetic use, exposure to a nursing infant via maternal milk is expected to be negligible. No authoritative cosmetic‑safety body (CIR/SCCS) reproductive clearance for this specific compound was located.

Is n,n'-methylenebisacrylamide safe for baby skin?

The hazard evidence (mouse developmental toxicity) supports a suspected reproductive/developmental hazard. Dermal exposure of infants (0–3 yr) is of greater concern than for adults because immature skin has higher surface‑area‑to‑weight and higher relative uptake; while adult topical cosmetic exposure is expected to be negligible, per the scoring rules infant exposure is increased by +1 when measurable absorption cannot be excluded. There are no infant‑specific toxicity data identified.

How does VeriMom score n,n'-methylenebisacrylamide?

VeriMom scores n,n'-methylenebisacrylamide at 39/100 (high risk) based on EU CosIng status, ECHA hazard classifications, and peer-reviewed PubMed studies. Our scoring pipeline is fully transparent.

What are pregnancy-safe alternatives to n,n'-methylenebisacrylamide?

See our curated list of pregnancy-safe alternatives to n,n'-methylenebisacrylamide based on similar function and a no-known-risks safety band.